CRISPR/CAS9 MUTAGENESIS REVEALS AN ESSENTIAL ROLE OF PI4KB IN PROMOTING GROWTH AND RESISTING HEMORRHAGIC DISEASE CAUSED BY GCRV-II INFECTION IN JUVENILE GRASS CARP

Few studies have reported obtaining grass carp resistant to hemorrhagic disease via gene editing in commercial fish.Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication.Given the obvious cytopathic effect (CPE) in the present available cell lines is only caused by GCRV-I, b

In the context of the increasing poverty rate due to the COVID-19 pandemic, it has become more difficult than ever to access housing opportunities.However, housing is a Bass Amp vital requisite for keeping oneself safe from the infection risk.Increasing poverty can increase homelessness and consequently the transmission of COVID-19.In addition, cro

Wet friction clutch is the key functional component of the high-speed helicopter variable-speed transmission system, which is used to change the power transmission path.In the engagement process of wet friction clutch, the driving/driven disc will produce drag torque under the shearing of lubricating oil, which reduces the transmission efficiency.T

Abstract Background Cognitive deficits arise with age and can increase the risk for subjective cognitive decline (SCD) and mild cognitive impairment (MCI), which may result in dementia, leading to health problems, care dependency and institutionalization.Computer-based cognitive interventions (CCIs) have the Books potential to act as important coun